DIAN PURNAMA DEWI, - (2020) VARIASI KONSENTRASI POLIVINIL ALKOHOL TERHADAP KARAKTERISTIK FISIK DAN AKTIVITAS ANTIBAKTERI ORALLY DISINTEGRATING FILM (ODF) EKSTRAK PECUT KUDA (Stachytarpheta jamaicencis L.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Pemberian obat melalui sediaan Orally Disintegrating Film (ODF) memberikan kemudahan dan kenyamanan bagi seluruh konsumen khususnya pasien yang mengalami kesulitan menelan serta memberikan waktu hancur yang cepat. Sediaan ODF mulai dikembangkan dengan memanfaatkan pecut kuda (Stachytarpheta jamaicencis L.) sebagai zat aktif. Komponen utama dalam sediaan ODF adalah polimer. Kombinasi HPMC K100M dengan Polivinil Alkohol sebagai film forming dapat membentuk ODF dengan karakteristik fisik yang baik. Penelitian ini dilakukan untuk mengetahui pengaruh kombinasi HPMC K100M dan variasi konsentrasi polivinil alkohol sebesar 1 gram; 1,5 gram; dan 2 gram terhadap karakteristik fisik ODF yang mengandung ekstrak pecut kuda. Tahapan penelitian yang dilakukan adalah formulasi basis dan sediaan kemudian dilakukan evaluasi fisik ODF dan uji aktivitas antibakteri. Hasil evaluasi karakteristik fisik sediaan ODF ekstrak pecut kuda yang terbaik yaitu pada formula 3 dengan konsentrasi polivinil alkohol sebesar 2 gram dengan pH permukaan 6,79±0,0152, bobot ratarata 0,05383±0,00134, tebal rata-rata 0,1200±0,00536, waktu hancur 55 detik, kekuatan tarik 44,048±3,8323 MPa, persen elongasi 60%, swelling index detik ke15; 30; dan 45 sebesar 287,79±0,1277%; 401,61±0,1389%; dan 420,63±0,3544% dan memiliki kemampuan antibakteri terhadap Staphylococcus aureus kategori kuat yaitu 21,63±1,8885 mm. --- Drug delivery through Orally Disintegrating Film (ODF) dosage form provides convenience and comfort for all consumers especially patients who have swallowing difficulty as well provides fast disintegration time. ODF dosage form developed by utilizing porterweed (Stachytarpheta jamaicencis L.) as active substance. The main component in ODF dosage form is polymer. The combination of HPMC K100M and Polyvinyl Alcohol as film forming could form good physical characteristics ODF. This research aims to determine the effect of HPMC K100M combination and variations in concentration of polyvinyl alcohol of 1 gram; 1.5 grams; and 2 grams to ODF physical characteristics containing extract of pecut kuda. This research conducted by formulating base and dosage form, physical evaluation of ODF and antibacterial activity tests were carried out subsequently. Physical characteristics evaluation of the optimum ODF dosage form of pecut kuda extract showed in formula 3 with polyvinyl alcohol concentration of 2 grams with 6.79 ± 0.0152 surface pH, 0.05383 ± 0.00134 average weight, 0,1200 ± 0.00536 average thickness, 55 seconds crush time, 44.048 ± 3.8323 mPa tensile strength, 60% elongation percent, swelling index at seconds of 15; 30; and 45 were 287.79 ± 0.1277%; 401.61 ± 0.13889%; and 420.63 ± 0.3544% and has strong antibacterial ability against Staphylococcus aureus of 21.63 ± 1.8885 mm.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Orraly Disintegrating Film (ODF), HPMC K100M, Polivinil alkohol, ekstrak pecut kuda (Stachytarpheta jamaicencis L.), Staphylococcus aureus --- Orally Disintegrating Film (ODF), HPMC K100M, Polyvinyl alcohol, porterweed extract (Stachytarpheta jamaicencis L.), Staphylococcus aureus |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 02:25 |
| Last Modified: | 02 Oct 2024 02:25 |
| URI: | http://repository.stfi.ac.id/id/eprint/1277 |
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