DEWI YUSTIKA SARI, - (2020) STUDI LITERATUR PENGARUH KOFORMER NIKOTINAMID DAN METODE PEMBENTUKAN KOKRISTAL TERHADAP KELARUTAN ZAT AKTIF TIDAK LARUT AIR. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Kokristalisasi merupakan salah satu teknik untuk meningkatkan kelarutan zat aktif farmasi yang 70% kelarutannya tidak larut dalam air. Kokristal terdiri dari zat aktif dan bahan tambahan yang disebut dengan koformer yang dihubungkan oleh interaksi non kovalen. Dalam studi ini akan dikemukakan review artikel terkait efek pembentukan kokristal dari zat aktif yang memiliki keterbatasan dalam kelarutan dengan menggunakan koformer nikotinamid. Nikotinamid berperan sebagai koformer larut air yang paling stabil. Zat aktif yang berhasil dibuat kokristal menggunakan metode solvent evaporation yaitu katekin, artesunat, ketoprofen, diflunisal, ibuprofen, simvastatin, dan prulifloxacin, menggunakan metode slurry diantaranya karbamazepin dan didanosin, sedangkan dengan metode liquid assisted grinding yaitu zaltoprofen dan furosemid. Peningkatan kelarutan zat aktif yang menggunakan solvent evaporation hingga 6 kali, menggunakan metode slurry hingga 1,86 kali, dan menggunakan metode liquid assisted grinding hingga 166.666,67 kali. Peningkatan kelarutan ini disebabkan adanya ikatan hidrogen yang terbentuk antara zat aktif dan koformer, serta karakterisasi yang menunjukan kokristal berhasil terbentuk, yaitu adanya fase kristal baru. Dalam review artikel dapat disimpulkan bahwa zat aktif yang telah dibentuk kokristal menggunakan koformer nikotinamid dengan beberapa metode yang berbeda menunjukkan peningkatan kelarutan hingga 166.666,67 kali. --- Cocrystallization is a technique to increase solubility of active pharmaceutical ingredient, which are 70% insoluble in water. Cocrystal consists of active pharmaceutical ingredient and additives called coformers which are connected by non-covalent interactions. In this study, a review of articles related to the effects of cocrystal formation from active pharmaceutical ingredient that have limited solubility using a nicotinamide coformer would be presented. Nicotinamide acted as the most stable water soluble coformer. The active pharmaceutical ingredient that have been successfully made by cocrystal using the solvent evaporation method was catechins, artesunate, ketoprofen, diflunisal, ibuprofen, simvastatin and prulifloxacin, using the slurry method was carbamazepine and didanosin, while the liquid assisted grinding method was zaltoprofen and furosemide. Increasing the solubility of active pharmaceutical ingredient using solvent evaporation up to 6 folds, using the slurry method until 1,86 folds, and using the liquid assisted grinding method up to 166.666,67 folds. This increase in solubility was due to the presence of hydrogen bonds formed between the active pharmaceutical ingredient and the coformer, as well as the characterization that showed the cocrystal has been successfully formed, namely the presence of a new crystal phase. Based on the review article, it can be concluded that the active pharmaceutical ingredient which has been formed by the cocrystal using a nicotinamide coformer with several different methods showed an increase in solubility up to 166,666.67 folds.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Kokristalisasi, Zat aktif tidak larut air, Nikotinamid, Kelarutan --- cocrystallization, water insoluble active pharmaceutical ingredient, nicotinamide, solubility |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 02:22 |
| Last Modified: | 02 Oct 2024 02:22 |
| URI: | http://repository.stfi.ac.id/id/eprint/1275 |
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