AGNES SHELVIANY, - (2020) PROFIL WAKTU HANCUR TABLET METODE GRANULASI BASAH MENGGUNAKAN VARIASI KARAGENAN SEBAGAI DISINTEGRAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Karagenan merupakan polisakarida yang terkandung di dalam rumput laut dari spesies Rhodophyta. Karagenan didapat dengan cara ekstraksi menggunakan larutan basa dengan suhu ekstraksi diantara 70-800C. Penelitian ini bertujuan untuk pengaplikasian karagenan dari hasil ekstraksi variasi basa dan nilai pH yaitu KOH pH 9, NaOH pH 9 dan Ca(OH)2 pH 13 pada sediaan tablet sebagai zat disintegran dengan model zat aktif parasetamol. Metode yang digunakan dalam pembuatan tablet parasetamol adalah granulasi basah. Konsentrasi karagenan yang digunakan pada penelitian ini yaitu masing-masing 5%, 10% dan 15% sehingga formula yang dibuat berjumlah 9 formula. Tablet yang dihasilkan dari tiap formula dievaluasi meliputi keseragaman ukuran, keseragaman bobot, kekerasan tablet, friabilitas, friksibilitas, kapasitas swelling dan pengujian waktu hancur. Berdasarkan data yang didapat untuk pengujian keseragaman ukuran, keseragaman bobot dan kekerasan tablet memenuhi persyaratan yang ditentukan. Pengujian kapasitas swelling dari waktu ke waktu mengalami penurunan bobot tablet. Pada pengujian waktu hancur tablet yang hancur pada rentang waktu 4-28 menit. Berdasarkan hasil evaluasi diketahui dari hasil penelitian bahwa F3, F5 dan F6 memenuhi persyaratan waktu hancur tablet oral. Konsentrasi karagenan yang menghasilkan waktu hancur yang paling cepat dari hasil ekstrak KOH pH 9 dengan konsentrasi 15%. --- Carrageenan is a polysaccharide contained in the seaweed of the Rhodophyta species. Carrageenan is obtained by extraction using an alkaline solution with an extraction temperature between 70-800C. This study aims to apply carrageenan from the extraction of various bases and pH values, namely KOH pH 9, NaOH pH 9 and Ca (OH) 2 pH 13 in tablet preparations as a disintegrant with the active substance model of paracetamol. The method used in the manufacture of paracetamol tablets is wet granulation. The carrageenan concentrations used in this study were 5%, 10% and 15%, respectively, so that the formulas made were 9 formulas. Tablets produced from each formula were evaluated including size uniformity, weight uniformity, tablet hardness, friability, friction, swelling capacity and crushed time testing. Based on the data obtained for testing the uniformity of size, uniformity of weight and hardness of the tablets meet the specified requirements. Swelling capacity testing from time to time decreased tablet weight. In the test disintegration time, the crushed tablets were in the range of 4-28 minutes. Based on the results of the evaluation, it is known from the research that F3, F5 and F6 meet the requirements for the disintegration of oral tablets. The carrageenan concentration that produced the fastest disintegration time was the KOH extract pH 9 with a concentration of 15%.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Karagenan, granulasi basah, parasetamol, disintegran tablet, uji waktu hancur. --- Carrageenan, wet granulation, parasetamol, disintegrant tablet, disintegration time test. |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 02:08 |
| Last Modified: | 02 Oct 2024 02:08 |
| URI: | http://repository.stfi.ac.id/id/eprint/1265 |
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