VALIDASI PENGUKURAN KADAR METANOL MENGGUNAKAN SPEKTROFOTOMETRI UV-VISIBLE DENGAN PENAMBAHAN REAGEN SCHIFF

TIRTA SUCI RAMADHANI, - (2022) VALIDASI PENGUKURAN KADAR METANOL MENGGUNAKAN SPEKTROFOTOMETRI UV-VISIBLE DENGAN PENAMBAHAN REAGEN SCHIFF. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Validasi metode analisis merupakan elemen penting dari kontrol kualitas, validasi memberikan jaminan bahwa pengukuran akan dapat diandalkan. Penelitian ini bertujuan untuk menetapkan validasi metode analisis kadar metanol menggunakan spektrofotometri uv-vis dengan penambahan reagen schiff. Metode ini dapat menjadi metode alternatif pengukuran kadar metanol namun belum ada data validasi sebelumnya. Parameter validasi yang ditetapkan yaitu presisi, akurasi, batas deteksi, batas kuantitasi, linieritas, dan selektivitas. Pengukuran dilakukan pada panjang gelombang maksimum 565 nm. Hasil penelitian menunjukkan akurasi yaitu 84,87%, presisi yaitu 0.5693%; batas deteksi sebesar 0,02457%, batas kuantitasi sebesar 0,08191 %, linearitas dengan koefisien kolerasi 0,9728, dan dengan rentang kosentrasi 0.0126%-0.1257%, untuk akurasi tidak memenuhi kriteria validasi dan uji selektivitas menunjukan bahwa metode ini tidak selektif. Ketidaksesuaian dua parameter menyebabkan metode analisis metanol dengan spekrtofotomer uv-vis dengan penambahan reagen Schiff tidak memenuhi standar validasi. --- Validation of analytical methods is an important element of quality control, and validation assures the reliability of measurements. The purpose of this study is to determine the validity of the method for analyzing the methanol content spectrophotometry uv-visble with the addition of the Schiff reagent. This method can be an alternative method of measuring methanol levels, but there is no previous validation data. The validation parameters are accuracy, precision ,limit of detection, limit of quantitation, linearity and selectivity. Measurements were performed at a maximum wavelength of 565nm. The results proved that the accuracy was 84.87%, precision was 0.5693%, limit of detection is 0.02457%, limit of quantitation is 0.08191 %, linearity with a correlation coefficient is 0.9728, and with a concentration range of 0.0126%-0.1257%, for accuracy, it does not comply with the validation criteria and the selectivity test shows that this method is not selective. The divergence of the two parameters causes the method of analysis of methanol with spectrophotometry uv-visible with the addition of the Schiff’sreagent does not comply with the validation standards.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Validasi Metode, Analisis Metanol, Reagen Schiff --- Validation Method, Methanol Analysis, Schiff's Reagent
Subjects:	Q Science > Q Science (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Sep 2024 14:03
Last Modified:	14 Sep 2024 14:03
URI:	http://repository.stfi.ac.id/id/eprint/1259

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