STUDI LITERATUR PENINGKATAN DISOLUSI OBAT SUKAR LARUT AIR MELALUI PEMBENTUKAN DISPERSI PADAT

SARI INDRIYANI, - (2022) STUDI LITERATUR PENINGKATAN DISOLUSI OBAT SUKAR LARUT AIR MELALUI PEMBENTUKAN DISPERSI PADAT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Sekitar 80-90% senyawa obat memiliki permasalahan kelarutan dan laju disolusi. Salah satu untuk mengatasi hal tersebut menggunakan metode dispersi padat. Telah banyak penelitian dan review journal membahas peningkatan disolusi obat sukar larut air melalui dispersi padat, tetapi belum ada yang merekomendasikan secara spesifik metode, polimer, dan variasi komponen efektif untuk meningkatkan laju disolusi. Tujuan review journal ini adalah menganalisis metode pembentukan, polimer, dan variasi komponen sistem dispersi padat yang efektif terhadap peningkatan laju disolusi. Review journal ini berupa systematic literature review menggunakan metode review PICOC (Population, Intervention, Comparison, Outcomes, and Context). Hasil review journal menunjukkan jenis polimer, variasi komponen, dan proses pembuatan mempengaruhi peningkatan disolusi zat aktif sukar larut air. Matriks hidrofilik PVA mampu meningkatkan disolusi tertinggi pada ketoprofen. Rasio obat:matriks 1:2 mampu meningkatkan disolusi pada asam mefenamat, diacerein, genistein, ketoprofen, dan meloksikam. Metode pelarutan telah berhasil mampu meningkatkan disolusi asam mefenamat, diacerein, genistein, glimepirid, ibuprofen, ketoprofen, meloksikam, dan natrium diklofenak. Matriks PVA dengan rasio ketoprofen:PVA 1:2 menggunakan metode pelarutan menunjukkan disolusi tertinggi pada ketoprofen, yaitu 15,8 kalinya. Berdasarkan review ini diperoleh kesimpulan bahwa penggunaan polimer yang sesuai dengan konsentrasi tertentu menggunakan metode perlarutan dalam pembentukan dispersi padat dapat berpengaruh siginifikan terhadap laju disolusi obat sukar larut air. --- About 80-90% of drug compounds have solubility and dissolution rate problems. One way to overcome is to use the solid-state dispersion method. There have been many studies and journal reviews discussing increasing the dissolution of watersoluble drugs by solid dispersions, but no one has specifically recommended methods, polymers, and variations of active components to increase the rate of dissolution. This journal review aims to analyse the formation methods, polymers and system variations of solid dispersion components that effectively increase the dissolution rate. This journal search is a systematic literature search using the PICOC (Population, Intervention, Comparison, Outcomes, and Context) review method. The results of the review journal show that the type of polymer, variety of components and manufacturing process influence the increase in the dissolution of poorly water-soluble drugs. The hydrophilic PVA matrix was able to increase the highest dissolution of ketoprofen. A drug:matrix ratio of 1:2 was able to increase the dissolution of mefenamic acid, diacerein, genistein, ketoprofen, and meloxicam.. The solvation procedure was successful in increasing the dissolution of mefenamic acid, diacerein, genistein, glimepiride, ibuprofen, ketoprofen, meloxicam, diclofenac sodium. PVA matrix with a 1:2 ketoprofen:PVA ratio using the dissolution method showed the highest dissolution of ketoprofen which was 15.8-fold. Based on this review, it was concluded that the use of polymers in certain concentrations using the solvation method in the formation of dispersions can significantly affect the rate of dissolution of poorly water-soluble drugs.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Dispersi padat, peningkatan disolusi, obat sukar larut air --- Solid dispersion, increased dissolution, poorly soluble drugs
Subjects:	Q Science > Q Science (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Sep 2024 14:23
Last Modified:	14 Sep 2024 14:23
URI:	http://repository.stfi.ac.id/id/eprint/1245

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