ERSYA NURRIA, - (2022) ISOLASI DAN UJI AKTIVITAS ANTIOKSIDAN SENYAWA AR-TURMERON DARI OLEORESIN KUNYIT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Ar-turmeron adalah salah satu senyawa yang terkandung dalam minyak atsiri kunyit yang diketahui memiliki aktivitas anti inflamasi, anti platelet, dan antikanker. Ar-turmeron berupa cairan berwarna kuning dan berbau aromatik. Penelitian ini bertujuan mengembangkan metode isolasi senyawa ar-turmeron dari oloeresin kunyit melalui proses penjerapan dengan beberapa adsorben, serta mengetahui aktivitas antioksidan dari ar-turmeron. Oleoresin kunyit sebagai bahan awal penelitian diperoleh melalui pengendapan ekstrak hasil maserasi kunyit. Oleoresin kunyit ditambahkan ke dalam penjerap untuk menghilangkan senyawa lainnya, ar-turmeron diperoleh dengan penarikan menggunakan etanol dengan proses pengocokan. Ar-turmeron diidentifikasi dengan metoda kromatografi lapis tipis, spektrofotometer uv-vis, dan kromatografi gas-spektrometri massa (GC-MS). Aktivitas antioksidan dari ar-turmeron diuji menggunakan metode DPPH (2,2difenil-1-pikrihidrazil). Adsorben yang memberikan hasil terbaik untuk isolasi ar-turmeron adalah silika gel. Ar-turmeron hasil isolasi menunjukkan pengurangan jumlah komponen dari 36 komponen menjadi 18 komponen serta meningkatnya persen area ar-tumeron menjadi 27,74% dengan waktu retensi 12,844 menit, serta serapan pada Panjang gelombang 233 nm dan pada pengujian KLT menunjukkan harga Rf = 0,5. ketiga hasil ini merupakan kekhasan dari ar-turmeron. Uji aktivitas antioksidan pada eluat etanol diperoleh nilai IC50 sebesar 20,11 ppm, menunjukan bahwa ar-turmeron memiliki aktivitas antioksidan dan dikategorikan antioksidan sangat kuat. --- Ar-turmerone is one of the compounds contained in turmeric essential oil which is known to have anti-inflammatory, antiplatelet, and anticancer activities. Arturmerone is a yellow liquid with an aromatic odor. This study aims to develop a method of isolation of ar-turmerone compounds from turmeric oleresin through the adsorption process with several adsorbents, and to determine the antioxidant activity of ar-turmerone. Turmeric oleoresin as the starting material of the study was obtained through the precipitation of extracts from maceration of turmeric. Turmeric oleoresin was added to the adsorbent to remove other compounds,arturmerone was obtained by withdrawal using ethanol with a shaking process. Arturmeron was identified by thin layer chromatography, UV-vis spectrophotometer, and gas-gas chromatography methods.mass spectrometry (GC-MS). The antioxidant activity of ar-turmerone was tested using the DPPH method (2,2diphenyl-1-picrihydrazil). The adsorbent that gave the best results for arturmerone isolation was silica gel. Ar-turmerone isolated results showreducing the number of components from 36 components to 18 components as well as increasing the percentage of ar-tumeron area to 27.74% withretention time12,844 minutes, as well as absorption at a wavelength of 233 nm and the TLC test shows the value of Rf = 0.5. these three results are typical of ar-turmerone. Antioxidant activity test on ethanol eluate obtained IC50 value of 20.11 ppm, indicating that ar-turmerone has antioxidant activity and is categorized as very strong antioxidant.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | oleoresin kunyit, ar-turmeron, silika gel, antioksidan --- turmeric oleoresin,ar-turmerone, silica gel, antioxidan |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 14 Sep 2024 15:03 |
| Last Modified: | 14 Sep 2024 15:03 |
| URI: | http://repository.stfi.ac.id/id/eprint/1229 |
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