KARAKTERISASI SIFAT FISIKA ISOLAT MANGOSTIN

ALVHIA SHALMA SAGITA, - (2022) KARAKTERISASI SIFAT FISIKA ISOLAT MANGOSTIN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Mangostin merupakan salah satu zat aktif utama berupa senyawa organik alami yang diisolasi dari kulit buah manggis. Sifat fisika yaitu sifat yang digunakan untuk menerangkan penampilan suatu zat. Tujuan dari penelitian ini untuk mendapatkan karakteristik fisika dari isolat mangostin sebagai kebutuhan dalam pengembangan formula sediaan yang mengandung isolat mangostin. Adapun pengujian yang dilakukan yaitu true density, tap density, penetapan kelarutan dengan pelarut PEG 400, propilen glikol, gliserin dan sorbitol, morfologi partikel dengan alat Scanning Electron Microscope (SEM), kristalinitas dengan X-Ray Diffraction (XRD), sifat termal dengan alat Differential Scanning Colorimeter (DSC) dan pengukuran nilai zeta potensial dengan alat Zeta Potensial Analyzer (ZPA). Hasil penelitian didapatkan nilai rata-rata indeks kompresibilitas yaitu 26,73%, nilai densitas kerapatan sejati isolat mangostin sebesar 0,782 g/mL, agak sukar larut dalam PEG 400, sangat sukar larut dalam propilen glikol, praktis tidak larut dalam gliserin dan sorbitol, % kristalinitas berbentuk amorf dengan rata-rata 78,8%, titik leleh 159,10oC, morfologi partikel berbentuk balok panjang seperti jarum, dan nilai zeta potensial dengan ratarata -65,17mV. Berdasarkan hasil penelitian dapat disimpulkan bahwa sampel mempunyai nilai indeks kompresibilitas yang kurang baik, memiliki densitas kerapatan sejati yang tidak mampat, berbentuk padatan amorf, dan mempunyai nilai potensial zeta yang baik. --- Mangostin is one of the main active substances in the form of natural organic compounds isolated from the skin of the mangosteen fruit. Physical properties are properties used to describe the appearance of a substance. The purpose of this study is to obtain the physical characteristics of mangostin isolates as a necessity in the development of dosage formulas containing mangostin isolates. The tests carried out are true density, tap density, determination of solubility with PEG 400 solvent, propylene glycol, glycerin and sorbitol, particle morphology with scanning electron microscope (SEM) tool, crystallinity with X-Ray Diffraction (XRD), thermal properties with Differential Scanning Colorimeter (DSC) tool and measurement of potential zeta values with tools Zeta Potential Analyzer (ZPA). The results of the study obtained the average value of the compressibility index, which was 26.73%, the true density density value of mangostin isolates was 0.782 g/mL, rather difficult to dissolve in PEG 400, very difficult to dissolve in propylene glycol, practically insoluble in glycerin and sorbitol, % amorphous crystallinity with an average of 78.8%, melting point 159.10oC, the morphology of long beam-like particles, and the value of potential zeta with an average of -65.17mV. Based on the results of the study, it can be concluded that the sample has a poor compressibility index value, has a true density density that is not clogged, is in the form of an amorphous solid, and has a good zeta potential value.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Densitas, Karakterisasi Fisika, Kristalinitas, Mangostin, Morfologi. --- Density, Characterization of Physics, Crystallinity, Mangostin, Morphology
Subjects:	Q Science > Q Science (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Sep 2024 15:31
Last Modified:	14 Sep 2024 15:31
URI:	http://repository.stfi.ac.id/id/eprint/1220

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