ADIK RIA SAFITRI, - (2022) UJI AKTIVITAS ANTIBAKTERI ISOLAT α-MANGOSTIN TERHADAP BAKTERI Enterococcus faecalis dan Salmonella typhi SECARA IN VITRO. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Infeksi merupakan penyakit menular yang disebabkan oleh bakteri, jamur, virus dan parasit. Bakteri yang dapat menyebabkan infeksi contohnya yaitu bakteri Enterococcus faecalis dan Salmonella typhi. Penggunaan antibiotik dianjurkan dalam pengobatan infeksi bakteri, namun ada beberapa mikroorganisme yang resistensi terhadap antimikroba. Resistensi mikroorganisme terhadap antimikroba membuat masyarakat mulai menggunakan obat dari bahan alam, diantaranya menggunakan kulit buah manggis. Isolat α-mangostin yang terkandung didalam buah manggis dapat menghambat pertumbuhan bakteri. Oleh karena itu, penelitian ini bertujuan untuk mengetahui apakah isolat α-mangostin dapat menghambat pertumbuhan bakteri Enterococcus faecalis dan Salmonella typhi dan menetapkan pada konsentrasi berapa isolat α-mangostin memberikan Konsentrasi Hambat minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) pada bakteri Enterococcus faecalis dan Salmonella typhi. Metode pengujian antibakteri yang digunakan adalah metode difusi menggunakan kertas cakram. Hasil dari uji aktivitas antibakteri isolat α-mangostin memiliki aktivitas antibakteri terhadap bakteri Enterococcus faecalis dan Salmonella typhi sebagai penghambat pertumbuhan bakteri tetapi tidak sebagai pembunuh bakteri, dimana isolat α-mangostin memiliki aktivitas antibakteri terhadap Enterococcus faecalis dengan nilai KHM yaitu 25 µg/mL, sedangkan terhadap Salmonella typhi dengan nilai KHM yaitu 250 µg/mL. --- Infection is a contagious disease caused by bacteria, fungi, viruses, and parasites. The kinds of bacteria that can cause infection are Enterococcus faecalis and Salmonella typhi. The usage of antibiotics is recommended in bacterial infection treatment. However, some microorganisms are resistant to antimicrobials. The resistance of a microorganism to the antimicrobials makes people start using medicines from natural inggredients, including a-mangosteen rind. The α-mangosteen isolate contained in the mangosteen can inhibit the growth of bacteria. Therefore, this study aims to determine whether α-mangosteen isolate can inhibit the growth of Enterococcus faecalis and Salmonella typhi bacteria and determine at what concentration the α-mangosteen isolate provides the Minimum Inhibitory Concentration (MIC) and Minimum Kill Concentration (MKC) on the bacteria Enterococcus faecalis and Salmonella typhi. The antibacterial research method used in this study is the diffusion method using disc paper. The result of the antibacterial activity test of α-mangosteen isolates against Enterococcus faecalis and Salmonella typhi bacteria as an inhibitor of bacterial growth but not as a bacteria killer, therefore α-mangosteen isolates had antibacterial activity against Enterococcus faecalis within MIC of 25 µg/mL, while against Salmonella typhi within MIC of 250 µg/mL.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | α-mangostin, antibakteri, Enterococcus faecalis, Salmonella typhi --- α-mangosteen, antibacterial, Enterococcus faecalis, Salmonella typhi |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 14 Sep 2024 15:34 |
| Last Modified: | 14 Sep 2024 15:34 |
| URI: | http://repository.stfi.ac.id/id/eprint/1218 |
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