NURJAMILAH HIDAYAT, - (2022) UJI AKTIVITAS ANTIDIABETES SENYAWA BAHAN ALAM BAWANG MERAH (Allium ascalonicum L.), JAHE (Zingiber officinale), DAN KAYU MANIS (Cinnamomum burmanii) SECARA IN SILICO. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Diabetes melitus merupakan suatu penyakit gangguan metabolisme karbohidrat yang ditandai dengan hiperglikemia sebagai akibat kekurangan insulin relatif, ketidakmampuan tubuh memproduksi insulin (absolut) atau ketidakmampuan insulin untuk mengontrol kadar gula darah. Diabetes melitus memiliki 4 tipe, yaitu diabetes melitus tipe 1, diabetes melitus tipe 2, diabetes melitus tipe gestasional, dan diabetes melitus tipe lain. Berdasarkan data dari Organisasi Internasional Diabetes Federation (IDF) Indonesia berada pada peringkat ke 7 diantara 10 negara dengan jumlah penderita terbanyak, yaitu sebesar 10,7 juta. Prevalensi terbanyak yaitu diabetes melitus tipe 2 sebesar 77% dari 100%. Berdasarkan penelitian sebelumnya, 11 senyawa dari bawang merah, jahe dan kayu manis diduga memiliki aktivitas antidiabetes. Tujuan penelitian ini untuk mengeksplorasi potensi senyawa bahan alam yang terkandung dalam bawang merah, jahe dan kayu manis dengan senyawa alliin, allisin, kaempferol, gingerol, paradol, shogaol, zingeron, metil hidroksi kalkon polimer, sinamaldehid, eugenol, dan proantosianidin sebagai antidiabetes secara in silico. Penelitian secara in silico ini dilakukan dengan menggunakan software Protein Ligand Ant System (PLANTS). Reseptor yang digunakan penelitian ini yaitu enzim alfa glukosidase dan PPRA- . Hasil penelitian menunjukkan bahwa dari 11 senyawa yang digunakan pada masing-masing reseptor ada 3 senyawa yaitu senyawa gingerol, paradol dan shogaol yang memiliki potensi lebih besar dengan masingmasing score docking -83,8245; -86,88371 dan -84,37788 dengan pembanding yang digunakan yaitu ref_ligand dengan senyawa -77,12472 sedangkan pembanding obat miglitol -77,02651 pada reseptor 2JKE dan 1 senyawa shogaol berpotensi dengan score docking -99,80825 yang mendekati dari pembanding, pembanding yang digunakan yaitu ref_ligand -116,0459 sedangkan pembanding obat thiazolidinedione -47,84001429 pada reseptor 1KNU. Hal ini menunjukkan bahwa senyawa yang diuji memiliki potensi untuk digunakan sebagai antidiabetes tipe 2 pada reseptor Inhibitor Alfa Glukosidase. --- Diabetes mellitus is a disease of carbohydrate metabolism disorders characterized by hyperglycemia as a result of relative insulin deficiency, the body's inability to produce insulin (absolute) or the inability of insulin to control blood sugar levels. There are 4 types of diabetes mellitus, namely type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and other types of diabetes mellitus. Based on data from the International Diabetes Federation (IDF), Indonesia ranks 7th out of 10 countries with the highest number of sufferers, namely 10.7 million. The highest prevalence was type 2 diabetes mellitus at 77% from 100%. Based on previous research, 11 compounds from onion, ginger and cinnamon are suspected to have antidiabetic activity. The purpose of this study was to explore the potential of natural compounds contained in shallots, ginger and cinnamon with compounds alliin, allisin, kaempferol, gingerol, paradol, shogaol, zingeron, methylhydroxy chalcone polymer, cinnamaldehyde, eugenol, and proanthocyanidin as antidiabetic in silico. This in silico research was conducted using the Protein Ligand Ant System (PLANTS) software. The receptors used in this study were alpha glucosidase and PPRA-γ enzymes. The results showed that of the 11 compounds used in each receptor, there were 3 compounds, namely gingerol, paradol and shogaol compounds which had greater potency with each docking score of - 83,8245; -86,88371 and -84,37788 which the comparisons used were ref_ligand with a docking score of -77,12472 meanwhile other comparisons used were miglitol drug with a docking score of -77,02651 at the 2JKE receptor and 1 potent shogaol compound with a docking score -99,80825 which approximates the ratio used were ref_ligand with a docking score of -116,0459, meanwhile other comparisons used thiazolidinedione drugs with docking score of - 47,84001429 at the 1KNU receptor. This indicates that the compound tested has the potential to be used as an antidiabetic type 2 at the alpha glucosidase inhibitor receptor.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | diabetes melitus, inhibitor alfa glukosidase, PPRA- , molecular docking --- diabetes melitus, alpha glucosidase inhibitor, PPRA-γ, molecular docking |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 14 Sep 2024 13:39 |
| Last Modified: | 14 Sep 2024 13:39 |
| URI: | http://repository.stfi.ac.id/id/eprint/1207 |
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