UJI AKTIVITAS ANTIVIRUS COVID-19 SENYAWA BAHAN ALAM SECARA IN SILICO

NABILLA DINDA JANNATIA, - (2022) UJI AKTIVITAS ANTIVIRUS COVID-19 SENYAWA BAHAN ALAM SECARA IN SILICO. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

	Text S_PSSF_A181077_Title.pdf Download (1MB)
	Text S_PSSF_A181077_Chapter1.pdf Restricted to Repository staff only Download (209kB)
	Text S_PSSF_A181077_Chapter2.pdf Restricted to Repository staff only Download (604kB)
	Text S_PSSF_A181077_Chapter3.pdf Restricted to Repository staff only Download (331kB)
	Text S_PSSF_A181077_Chapter4.pdf Restricted to Repository staff only Download (357kB)
	Text S_PSSF_A181077_Chapter5.pdf Restricted to Repository staff only Download (200kB)
	Text S_PSSF_A181077_Appendix.pdf Restricted to Repository staff only Download (1MB)

Abstract

Coronavirus Disease 2019 (COVID-19) yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yang dimana COVID-19 ini telah menjadi wabah secara global. Upaya pencarian obat antivirus untuk COVID19 ini diawali dengan melakukan skrining terhadap beberapa senyawa yang berasal dari tanaman melalui studi in silico, dengan molecular docking. Penelitianpenelitian sebelumnya tentang skrining senyawa antivirus COVID-19 telah dilakukan, namun peluang menemukan senyawa - senyawa yang mempunyai aktivitas potensial masih diperlukan. Pada penelitian ini akan diuji senyawa - senyawa aktif dari bawang merah, cabai merah, daun kelor, jambu biji, kakao, kelapa, secang, sorgum, tempe, dan ubi jalar yang telah dilaporkan memiliki aktivitas antivirus. Metode in silico yang digunakan adalah molecular docking. Adapun program penunjang penelitian ini adalah program PLANTS® (Protein-Ligand Ant System). Berdasarkan hasil validasi docking didapatkan bahwa target yang digunakan yaitu 3E9S dan 6LU7 valid, dengan RMSD 0,5519 Amstrong dan 1,912 Amstrong. Hasil docking menunjukkan bahwa dari 19 senyawa yang diteliti, dihidrokapsaisin memiliki interaksi terbaik dibandingkan senyawa lainnya terhadap 3E9S dengan skor docking -109,57, sedangkan senyawa kuersetin-3-4- diglikosida menunjukkan interaksi terbaik pada target 6LU7 dengan skor docking -100,2. --- Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) where COVID-19 has become a global outbreak. The search for antiviral drugs for COVID-19 was initiated by screening several compounds derived from plants through in silico studies, with molecular docking. Previous studies on screening for COVID-19 antiviral compounds have been carried out, but the opportunity to find compounds that have potential activity is still needed. In this study, the active compounds of shallots, red chilies, moringa leaves, guava, cocoa, coconut, secang, sorghum, tempeh, and sweet potato have been reported to have anti-viral activity. The in silico method used is molecular docking. The program supporting this research is the PLANTS® (Protein-Ligand Ant System) program. Based on the results of the docking validation, it was found that the targets used were 3E9S and 6LU7 valid, with RMSD 0,5519 Armstrong and 1,912 Armstrong for 6LU7. The docking results showed that of the 19 compounds studied, dihydrokapsaisin had the best interaction compared to other compounds against 3E9S with a docking score of -109.57, while the compound quer-cetin-3-4-diglycoside showed the best interaction on the 6LU7 target with a docking score of -100, 2.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Antivirus, COVID-19, docking, in silico, PLANTS. --- Antiviral, COVID-19, docking, in silico, PLANTS.
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Sep 2024 13:27
Last Modified:	14 Sep 2024 13:27
URI:	http://repository.stfi.ac.id/id/eprint/1201

Actions (login required)

View Item