STUDI LITERATUR PARAMETER YANG MEMPENGARUHI LOADING CAPACITY DAN LOADING EFFICIENCY SUATU OBAT KE DALAM MESOPORI

MASSYIFA NURIYAH AGUSTINI, - (2022) STUDI LITERATUR PARAMETER YANG MEMPENGARUHI LOADING CAPACITY DAN LOADING EFFICIENCY SUATU OBAT KE DALAM MESOPORI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Mesopori adalah material solid yang berpori dengan luas permukaan spesifik 1.500 m2 /g, volume pori 1,5 cm3 /g, dan ukuran pori 2 hingga 50 nm. Mesopori berfungsi sebagai penghantar obat sehingga loading capacity dan loading efficiency suatu mesopori menjadi sangat penting untuk dipertimbangkan. Loading capacity dan loading efficiency mempengaruhi sistem penghantaran obat, efektivitas produksi, dan kerja obat. Studi literatur ini bertujuan untuk mengetahui parameter yang mempengaruhi loading capacity dan loading efficiency suatu obat ke dalam mesopori. Studi literatur disusun berupa systematic literature review menggunakan metode PICOC (Population, Intervention, Comparison, Outcomes, Context). Dari hasil studi literatur diketahui bahwa formula mesopori yang dapat menghasilkan loading capacity dan loading efficiency yang baik adalah mesopori hasil kombinasi prekursor TEOS (Tetraethyl orthosilicate) dan template CTAB (Cetyltrimethylammonium Bromide) menggunakan metode sol-gel. Karakteristik mesopori juga mempengaruhi loading capacity dan loading efficiency. Semakin besar ukuran dan volume pori, semakin tinggi nilai loading capacity dan loading efficiency. Sementara itu, luas permukaan pori belum menunjukkan adanya liniearitas dengan loading capacity dan loading efficiency. Berdasarkan studi literatur ini, dapat disimpulkan bahwa formula, metode pembuatan, dan karakteristik ukuran serta volume pori berpengaruh terhadap loading capacity dan loading efficiency suatu obat dalam mesopori. --- Mesopores are porous solids with a specific surface area of 1,500 m2 /g, a pore volume of 1.5 cm3 /g and a pore size of 2 to 50 nm. Mesopores have the function as drug carriers, so the loading capacity and loading efficiency of a mesopore are very important are taken into account. Loading capacity and loading efficiency affect drug delivery system, production efficiency and drug effect. This literature study aims to determine the parameters that affect the loading capacity and loading efficiency of a drug into the mesopores. The literature study was created in the form of a systematic literature search using the PICOC method (Population, Intervention, Comparison, Outcomes, Context). The result shows that the mesoporous formula, which can produce good loading capacity and loading efficiency, as a result of combining TEOS (tetraethyl orthosilicate) precursor and CTAB (cetyltrimethylammonium bromide) template using the sol-gel method. Mesoporous properties also affect loading capacity and loading efficiency. The larger the pore size and volume, the higher the loading capacity and loading efficiency. Meanwhile, the pore surface has not shown linearity with loading capacity and loading efficiency. Based on this literature study, it can be concluded that the formula, the manufacturing process, and the characteristics of the size and volume of the pores affect the loading capacity and loading efficiency of a drug in the mesopores.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Mesopori, loading capacity, loading efficiency --- Mesoporous, loading capacity, loading efficiency
Subjects:	R Medicine > R Medicine (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Sep 2024 04:53
Last Modified:	14 Sep 2024 04:53
URI:	http://repository.stfi.ac.id/id/eprint/1190

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