JAN REZA PUTRA, - (2022) STUDI LITERATUR PENINGKATKAN KELARUTAN DAN DISOLUSI KOAMORF OBAT SUKAR LARUT AIR GOLONGAN ASAM KARBOKSILAT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Beberapa obat termasuk dalam kelompok asam karboksilat yang sedikit larut dalam air. Obat yang sukar larut dalam air dapat menyebabkan disolusi dan bioavailabilitas yang buruk sehingga menghambat aktivitas obat. Salah satu solusi untuk mengatasi masalah tersebut adalah dengan pembentukan koamorf. Kajian literatur ini bertujuan untuk mengetahui pengaruh pembentukan koamorf terhadap peningkatan kelarutan dan disolusi obat golongan asam karboksilat. Kajian yang disusun berupa systematic review journal menggunakan protokol PICOC (Population, Intervention, Comparison, Outcomes, and Context). Tinjauan literatur menunjukkan koamorf binary system furosemid menggunakan verapamil HCl sebagai koformer dengan rasio molar 1:2 mengalami peningkatan kelarutan terendah yaitu 0,07 kali dan koamorf binary system indometasin menggunakan histidin sebagai koformer dengan rasio molar 1:1 mengalami peningkatan disolusi terendah, yaitu sebesar 1,25 kali. Koamorf ternary system valsartan menggunakan arginin dan histidin sebagai koformer dengan rasio molar 1:1:1 mengalami peningkatan kelarutan dan disolusi sebesar 222 kali dan 1260 kali secara berturutturut. Ikatan hidrogen dan pembentukan garam bertanggung jawab atas peningkatan kelarutan dan disolusi valsartan. Berdasarkan kajian literatur ini disimpulkan bahwa strategi terbaik untuk mendapatkan koamorf yang memiliki kelarutan dan disolusi tinggi adalah koamorf sistem ternary pada rasio molar 1:1:1 menggunakan koformer golongan asam amino (arginin) dan metode milling yang mampu membentuk ikatan hidrogen dan garam. --- Some drugs belong to the group of poorly water-soluble carboxylic acids. Drugs that are poorly soluble in water can cause poor dissolution and bioavailability, thereby inhibiting drug activity. One solution to overcome this problem is the formation of coamorphous. This literature review aims to determine the effect of coamorphous formation on increasing the solubility and dissolution of carboxylic acid drugs. The study was created in the form of a systematic review journal according to the PICOC protocol (Population, Intervention, Comparison, Outcomes, and Context). The literature review showed that the coamorphous of the binary system of furosemide using verapamil HCl as a coformer with a 1:2 molar ratio had the lowest increase in solubility of 0.07-fold and the binary coamorph of the indomethacin system using histidine as the Coformer with a 1:1 molar ratio experienced the lowest increase in resolution of 1.25 times. The valsartan ternary coamorphous system using arginine and histidine as coformers in a 1:1:1 molar ratio experienced a 222-fold and 1260-fold increase in solubility and resolution, respectively. Hydrogen bonding and salt formation are responsible for the increased solubility and dissolution of valsartan. Based on this literature review, it was concluded that the best strategy to obtain a coamorphous with high solubility and disolution was a ternary system coamorphous in a 1:1:1 molar ratio using amino acid group coformers (arginine) and milling methods that are capable of forming hydrogen bonds and salts.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Koamorf, kelarutan, disolusi, obat sukar larut air. ---- Coamorphous, solubility, dissolution, slightly solube drugs |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 14 Sep 2024 04:39 |
| Last Modified: | 14 Sep 2024 04:39 |
| URI: | http://repository.stfi.ac.id/id/eprint/1183 |
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