NENI MULYATI, - (2021) UJI AKTIVITAS INSULIN-SENSITIZER TEH HERBAL DAUN ASHITABA (Angelica Keiskei (Miq.) Koidz.) PADA MENCIT SWISS WEBSTER. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
![[img]](http://repository.stfi.ac.id/style/images/fileicons/text.png) |
Text
S_PSSF_A171089_Title.pdf Download (5MB) |
|
Text
S_PSSF_A171089_Chapter1.pdf Restricted to Repository staff only Download (956kB) |
|
Text
S_PSSF_A171089_Chapter2.pdf Restricted to Repository staff only Download (5MB) |
|
Text
S_PSSF_A171089_Chapter3.pdf Restricted to Repository staff only Download (2MB) |
|
Text
S_PSSF_A171089_Chapter4.pdf Restricted to Repository staff only Download (4MB) |
|
Text
S_PSSF_A171089_Chapter5.pdf Restricted to Repository staff only Download (203kB) |
|
Text
S_PSSF_A171089_Appendix.pdf Restricted to Repository staff only Download (3MB) |
Abstract
Secara empiris daun Ashitaba (Angelica keiskei (Miq.) Koidz.) digunakan oleh masyarakat Lombok untuk mengobati diabetes. Penelitian ini bertujuan untuk mengetahui aktivitas sensitivitas insulin pada sediaan teh herbal daun ashitaba. Teh herbal dibuat dalam dua variasi konsentrasi yaitu 1% b/v (Uji I) dan 3,3% b/v (Uji II). Pengujian insulin-sensitizer menggunakan 5 kelompok mencit yaitu kelompok kontrol normal, kontrol negatif, kontrol positif (metformin) dan 2 kelompok uji, yaitu uji I dan uji II. Setiap kelompok diberi induksi dengan emulsi tinggi lemak selama 10 hari kecuali pada mencit kontrol normal. Pada kontrol positif diberikan suspensi metformin, dan pada kelompok uji 1 dan uji II diberikan teh hesbal daun ashitaba selama 7 hari. Tes toleransi insulin dilakukan selama 1 hari setelah pemberian perlakuan untuk menilai aktivitas insulin-sensitizer. Hasil pengujian menunjukkan peningkatan sensitivitas insulin pada setiap kelompok uji (p<0,05), dinilai dengan cara membandingkan nilai konstanta tes toleransi insulin (Kyrı) kelompok uji terhadap kelompok kontrol negatif, Nilai Kr pada kedua kelompok uji lebih besar dari kelompok kontrol negatif yaitu 53,95 dan 58,83. Teh herbal daun ashitaba menunjukkan aktivitas meningkatkan sensitivitas insulin pada mencit jantan yang diinduksi emulsi tinggi lemak. --- Empirically Ashitaba leaves (Angelica keiskei (Miq.) Koidz.) are used by the people of Lombok to treat diabetes. This study aims to determine the activity of insulin sensitivity in ashitaba leaf herbal tea preparations. Herbal teas were made in two concentration variations, namely 1% w/v (Test 1) and 3.3% w/v (Test 11). The insulin-sensitizer test used 5 groups of mice, namely normal control, negative control, positive control (metformin) and 2 test groups, namely test 1 and test II. Each group was induced with a high-fat emulsion for 10 days except for normal control mice. The positive control was given metformin suspension and the test group I and test II were given ashitaba leaf herbal tea for 7 days. Insulin tolerance test was carried out for 1 day after treatment to assess insulin-sensitizer activity. The test results showed an increase in insulin sensitivity in each test group (p<0.05), assessed by comparing the vaine of the ursulin tolerance test constant (Krn) of the test group to the negative control group. Kin vahies in both test groups were greater than the negative control group, namely 53.95 and 58.83. Ashitaba leaf herbal tea showed activity to increase insulin sensitivity in male mice induced by high fat emulsion.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Daun Ashitaba (Angelica keisket (Miq.) Koidz.), Diabetes Melitus, Insulin-Sensitzer --- Aslutaba Leaf (Angelica keisker (Mig) Koidz), Diabetes Melitus, Insulin-Sensnizer |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 07 Sep 2024 01:44 |
| Last Modified: | 07 Sep 2024 01:44 |
| URI: | http://repository.stfi.ac.id/id/eprint/1157 |
Actions (login required)
 |
View Item |
