DEVIRA LUKITA, - (2021) REVIEW: AKTIVITAS INHIBITOR ENZIM ALFA- GLUKOSIDASE DAN ALFA-AMILASE DARI EKSTRAK TUMBUHAN FABACEAE SUBFAMILI MIMOSOIDEAE. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Salah satu strategi penting untuk mengobati diabetes mellitus tipe II adalah penghambatan enzim alfa-glukosidase yang dapat mengontrol postprandial hiperglikemia dan penghambatan enzim alfa-amilase yang dapat mengontrol pencernaan karbohidrat. Review ini bertujuan untuk mengumpulkan informasi tentang potensi ekstrak famili Fabaceae subfamili Mimosoideac sebagai inhibitor alfa-glukosidase dan alfa-amilase menggunakan Google Scholar dan Research Gate dari beberapa publikasi ilmiah baik nasional maupun internasional. Hasil yang diperoleh dari beberapa studi literatu menunjukkan bahwa Fabaceac dapat dimanfaatkan sebagai obat antidiabetes. Subfamili Mimosoideae merupakan subfamili yang paling berperan dalam menghambat aktivitas enzim alfa- glukosidase dan enzim alfa-amilase. Ekstrak kulit biji Entada rheedii Spreng, ekstrak kulit pohon Albizia lebbeckoides (DC.) Benth dan Cathormion umbellatum (Vahl) Kosterm, ekstrak kulit batang Pithecellobium dulce Benth, ekstrak Xylia xylocarpa (Roxb.) Taub, ekstrak heksana kulit batang Albizia lebbeck (L.) Bent memiliki aktivitas inhibitor alfa-glukosidase dan alfa-amilase yang cukup kuat di antara tumbuhan Fabaceae lainnya. Potensi ekstrak metanol Mimosa pudica Linn, ekstrak metanol daun Adenanthera pavonina, ekstrak etanol akar Albizia antunesiana, dan ekstrak etanol kulit batang Leucaena leucocephala (Lam) De Wit lebih baik dibandingkan terhadap kontrol positif jika dilihat dari ICso atau persen inhibisi alfa-glukosidase dan alfa-amilase pada konsentrasi tertentu. --- One of the important strategies to treat type II diabetes mellitus is the inhibition of the enzyme alpha-glucosidase which can control postprandial hyperglycemia and inhibition of the enzyme alpha-amylase which can control carbohydrates. This review aims to collect information about the potential of extracts from the family Fabaceae subfamily Mimosoideae as alpha-glucosidase and alpha-amylase inhibitors using Google Scholar and Research Gate from several scientific publications both nationally and internationally. The results used from several literature studies show that Fabaceae can be used as an antidiabetic drug. The Mimosoideae subfamily is the subfamily that plays the most role in inhibiting the activity of the alpha-glucosidase and alpha-amylase enzymes. Entada rheedii Spreng seed bark extract, Albizia lebbeckoides (DC.) Benth tree bark extract and Cathormion umbellatum (Vahl) Kosterm, Pithecellobium dulce Benth bark extract, Xylia xylocarpa (Roxb.) Taub extract, Albizia bark hexane extract had lebbeck Bent activity. Alpha-glucosidase and alpha-amylase inhibitors are quite strong among other Fabaceae plants. The potency of Mimosa pudica Linn methanol extract, Adenanthera pavonina leaf methanol extract, Albizia antunesiana root ethanol extract, and Leucaena leucocephala (Lam) stem bark ethanol extract was better than positive control when viewed from ICso or percent inhibition of alpha- glucosidase and alpha-amylase at certain concentrations.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | amilase, diabetes mellitus, ekstrak, fabaccae, glukosidase --- amylase, diabetes mellitus, extract, fabaceae, glucosidase |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 07 Sep 2024 02:03 |
| Last Modified: | 07 Sep 2024 02:03 |
| URI: | http://repository.stfi.ac.id/id/eprint/1144 |
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