SINTESIS DAN KARAKTERISASI MOLECULARLY IMPRINTED POLYMER MICROSPHERES YANG SELEKTIF TERHADAP ANDROGRAFOLID

YUSHAR RAMADHAN, - (2021) SINTESIS DAN KARAKTERISASI MOLECULARLY IMPRINTED POLYMER MICROSPHERES YANG SELEKTIF TERHADAP ANDROGRAFOLID. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Andrografolid adalah komponen utama dari Andrographis Paniculata Ness, dengan berbagai aktivitas biologis. Karena pentingnya efek farmakologis, maka perlu dikembangkan metode isolasinya. Molecularly imprinted polymer microspheres (MIPs) dapat digunakan untuk isolasi andrografolid karena dapat didesain selektif terhadap senyawa tertentu yang menjadi tempiatenya. Penelitian ini dilakukan untuk mensintesis, mengkarakterisasi, menentukan waktu dan berat optimum adsorben yang dapat berinteraksi dengan andrografolid. Metode pencetakan permukaan digunakan untuk mensintesis MIP. Andrographolide, 3- Aminopropyltriethoxylane (APTES), Tetraethyl orthosilicate (TEOS), dan metanol masing-masing digunakan sebagai molekul template, monomer fungsional, pengikat silang dan pelarut porogen. MIP disintesis dengan memvariasikan perbandingan molekul templat, monomer fungsional dan crosslinker, dalam penelitian ini digunakan perbandingan 1:4:100 dan 1:5:100. MIP dikarakterisasi dengan Fourier transform Infra-Red (FTIR) dan High Performance Liquid Chromatography (HPLC), Hasil karakterisasi menunjukkan andrografolid berhasil menempel pada polimer. Dari studi waktu optimum dan berat adsorben didapatkan waktu optimum adalah 20 menit dan berat optimum adalah 10 mg. --- Andrographolide is the major component of Andrographis Paniculata Ness, with various biological activities. Because of the important of pharmacological effects, It is necessary to develop its isolation method. Molecularly imprinted polymer microspheres (MIPs) can be used for andrographolide isolation because they can be designed to be selective for certain compounds that become their templates. This study was conducted to synthesize, characterize, determine the optimum time and weight of the adsorbent that can interact with andrographolide. Surface imprinting method was used to synthesis MIPs. Andrographolide, 3-Aminopropyltriethoxylane (APTES), Tetraethyl orthosilicate (TEOS), and methanol was used as template molecule, functional monomer, crosslinker and porogen solvent respectively. MIPs was synthesized by variating the comparison of template molecule, functional monomer and crosslinker, in this study 1:4 :100 and 1:5:100 comparison was employed. MIPs was characterized by Fourier transform Infra-Red (FTIR) and High Performance Liquid Chromatography (HPLC). Characterization result showed that andrographolide was successfully attached to the polymer. From the optimum time and adsorbent weight study it can be found that the optimum time was 20 minutes and the optimum weight was 10 mg.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Silika mikrosfer, Molecularly Imprinted Polymer (MIP), Andrografolid, APTES, TEOS, surface imprinting. --- Silica microspheres, Molecularly Imprinted Polymer Microspheres (MIPs), Andrographolide, APTES, TEOS, surface imprinting.
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	07 Sep 2024 02:14
Last Modified:	07 Sep 2024 02:14
URI:	http://repository.stfi.ac.id/id/eprint/1133

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