YULIZA, - (2021) PENGGUNAAN KARAGENAN HASIL EKSTRAKSI Ca(OH)2 SEBAGAI BAHAN PENGISI SEDIAAN TABLET. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Produksi rumput laut sebagian besar berupa bahan baku dan belum digunakan secara luas, sedangkan karagenan yang merupakan produk turunan rumpy laut dapat digunakan dibidang farmasi. Karagenan dapat diperoleh dengan cara ekstraksi dari rumput laut dengan menggunakan pelarut alkali yaitu Ca(OH)2. Penelitian ini bertujuan untuk pembuatan tablet dengan bahan pengisi dari karagenan dan mendapatkan karakteristik tablet yang sesuai dengan persyaratan. Adapun metode penelitian meliputi pengujian karakteristik fisika padatan karagenan dan hasilnya sesuai dengan standar karakteristik fisika padatan sebagai eksipien, selanjutnya formulasi tablet, evaluasi massa siap cetak, pencetakan tablet dan evaluasi tablet. Formula yang terdiri dari F1, F2, F3, F4, dan F5, adapun formula 3 (F3) adalah formula yang memenuhi persyaratan karena laju alirnya 14,4 g/s, sudut istirahat 23,71°, kompresibilitas 15,94%, rasio hausner 1,19, rendemen tablet asetosal 83,33%, diameter tablet 0,79±0 cm dan tebal 0,420 +0,003 cm, keseragaman bobot 0,302 + 0,005g, kekerasan tablet 5,35 +0,48 kg/cm³, friabilitas 0,32%, friksibilitas 0,64%, waktu hancur 3,09 menit. Dapat disimpulkan bahwa karagenan hasil ekstraksi Ca(OH)2 dapat digunakan sebagai bahan pengisi pada tablet serta pengujian evaluasi tablet, rata-rata semua formula masuk dalam persyaratan pengujian. --- Kelp creation is for the most part as unrefined components and has not been broadly utilized, while carrageenan which is a subsidiary result of ocean growth can be utilized in the drug area. Carrageenan can he gotten by separating kelp utilizing a basic dissolvable, specifically Ca(OH)2. That review intends to make tablets with carrageenan as a filler and to acquire tablet qualities that meet the prerequisites. The examination strategy incorporates testing the actual qualities of carrageenan solids and the outcomes are as per the standard actual attributes of solids as excipients, then, at that point, tablet definition, assessment of prepared to-print mass, tablet printing and tablet assessment. Equation comprising of F1, F2, F3, F4, and FS, while recipe 3 (F3) is an equation that meets the prerequisites on the grounds that the stream rate is 14.4 g/s, point of rest 23.71o, compressibility 15.94%, hausner proportion 1.19, acetosal tablet yield was 83.33%, tablet measurement 0.79+0 cm and thickness 0.420 +0.003 cm, weight consistency 0.302 +0.005g, tablet hardness 5.35 +0.48 kg/cm3, friability 0, 32%, 0.64% grating, deterioration time 3.09 mimites. It tends to be presumed that the separated carrageenan Ca(OH)2 can be utilized as a filler in tablets just as tablet assessment tests, on normal all recipes are remembered for the test necessities.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Karagenan, Kempa Langsung, Asetosal, Karakteristik Fisika Padatan --- Carrageenan, Direct Compression, Acetosal, Physical Characteristics of Solids |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 07 Sep 2024 02:15 |
| Last Modified: | 07 Sep 2024 02:15 |
| URI: | http://repository.stfi.ac.id/id/eprint/1132 |
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