PENGARUH WAKTU PENGERINGAN PADA SINTESIS MESOPORI SILIKA NANOPARTIKEL TERHADAP LOADING CAPACITY DAN LOADING EFFICIENCY ETIL P-METOKSISINAMAT

PUSPITA DEWI, - (2021) PENGARUH WAKTU PENGERINGAN PADA SINTESIS MESOPORI SILIKA NANOPARTIKEL TERHADAP LOADING CAPACITY DAN LOADING EFFICIENCY ETIL P-METOKSISINAMAT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Mesopori silika nanopartikel (MSN) meningkatkan kelarutan obat sukar larut air karena memiliki pori berukuran nano. Pori MSN menjerap obat dan menyebabkan penurunan ukuran partikel, penurunan kristalinitas, dan pencegahan rekristalisasi obat. Volume pori merupakan faktor penting dalam pemuatan zat aktif dan dipengaruhi oleh waktu pengeringan. Etil p- metoksisinamat (EPMS) merupakan senyawa sukar larut air yang dapat dimuat ke dalam MSN. Penelitian ini bertujuan untuk melihat pengaruh waktu pengeringan MSN terhadap loading capacity (LC) dan loading efficiency (LE) EPMS. MSN dibuat menggunakan prekursor natrium silika dan template berupa tween 80 dan span 80. MSN dikeringkan pada suhu 50 °C selama 24 jam, 72 jam, dan lebih dari 72 jam. EPMS dimuat kedalam MSN dengan perbandingan 1:2 selama 24 jam. LC dan LE EPMS-MSN dianalisis. Ukuran partikel, luas permukaan, diameter dan volume pori, morfologi dalam, gugus fungsi, dan kristalinitas MSN dikarakterisasi. Hasil penelitian menunjukkan EPMS termuat ke dalam MSN dengan nilai LC 3,2-10,6% dan nilai LE 4,45-18,18%. MSN memiliki bentuk tidak beraturan, ukuran partikel 87,1305 nm, luas permukaan 68,86 m²/g, diameter pori 20,45 nm, volume pori 0,352 cm³/g, dan kristalinitas yang rendah. Dengan demikian, dapat disimpulkan bahwa waktu pengeringan berpengaruh terhadap pemuatan EPMS ke dalam MSN --- Mesoporous silica nanoparticles (MSN) increase the solubility of poorly water- soluble drugs because they have nano-sized pores. MSN pores adsorb the drug and cause a decrease in particle size, decrease in crystallinity, and prevention of drug recrystallization. Pore volume is an important factor in loading the active substance and is affected by drying time. Ethyl p-methoxycinnamate (EPMC) is a poorly water-soluble compound that can be loaded into MSN. This study aims to see the effect of MSN drying time on the loading capacity (LC) and loading efficiency (LE) of EPMC, MSN was assembly by using sodium silica as precursor and tween 80 and span 80 as template. MSN was dried at 50°C for 24 hours, 72 hours, and more than 72 hours. EPMC was loaded into MSN at a ratio of 1:2 for 24 hours. LC and LE EPMC-MSN were analyzed. Particle size, surface area, pore diameter and volume, internal morphology, functional groups, and crystallinity of MSN were characterized. The results showed that EPMC was loaded into MSN with LC values of 3.2-10.6% and LE values of 4.45- 18.18%. MSN has an irregular shape, particle size 87.1305 nm, surface area 68.86 m²/g, pore diameter 20.45 nm, pore volume 0.352 cm³/g, and low crystallinity. It can be concluded that the drying time affects the loading of EPMC into MSN.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	: Mesopori Silika Nanopartikel, Etil p-Metoksisinamat, Loading capacity, loading efficienc --- Mesoporous Silica Nanoparticles, Ethyl p-Methoxycinnamate, Loading capacity, Loading efficiency.
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	07 Sep 2024 02:54
Last Modified:	07 Sep 2024 02:54
URI:	http://repository.stfi.ac.id/id/eprint/1119

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