PRETTY NURWANSARI, - (2021) EFEKTIVITAS DAN FREKUENSI KEJADIAN EFEK SAMPING PENGGUNAAN OBAT KAPTOPRIL DAN AMLODIPIN PADA PASIEN HIPERTENSI DI UPTD PUSKESMAS PAMULIHAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Hipertensi adalah kondisi medis yang kronis dimana tekanan darah meningkat di atas tekanan darah yang disepakati normal. Penelitian ini bertujuan untuk membandingkan efektivitas dan efek samping kaptopril dan amlodipin terhadap penurunan tekanan darah di UPTD Puskesmas Pamulihan periode 2020. Jenis penelitian ini bersifat non eksperimental dilakukan secara retrospektif. Dengan teknik pengambilan sampel sesuai dengan kriteria inklusi, data dianalisis secara univariat dan bivariat dengan menggunakan SPSS (Uji friedman, Wilcoxon, kruskall-wallis, Mann-Whitney, Chi-Square dan Fisher Exact). Hasil menunjukkan bahwa kaptopril dapat menurunkan tekanan darah 25.54/8.51 mmHg dan amlodipin dapat menurunkan tekanan darah 28.64/6.85 mmHg setelah pemeriksaan ke-3. Persentase untuk kejadian efek samping akibat penggunaan kaptopril 98.61% dengan efek samping batuk kering dan mulut kering. sedangkan untuk amlodipin 88.88% dengan efek samping pembengkakan pada pergelangan kaki. Perbandingan efektivitas antara kaptopril dan amlodipine tidak ada perbedaan, dikarenakan nilai Asymp sig. (2-talled) melebihi nilai 0,05 yaitu pada pemeriksaan ke-2, tekanan darah sistolik 0,519 dan diastolik 0,839. Hasil pemeriksaan tekanan darah ke-3 didapatkan nilai sistolik 0,616 dan diastolik 0.313. Pada perbandingan efek samping antara obat kaptopril dan amlodipin didapatkan nila nilai Asymp sig. (2- tailed) melebihi nilai 0,05 yaitu 0.533 artinya tidak ada perbedaan yang signifikan. --- Hypertension is a chronic medical condition in which blood pressure rises above the agreed normal blood pressure. This study aims to compare the effectiveness and xide effects of captopril and amlodipine on reducing blood pressure in the UPTD Puskesmas Pamulihan period 2020. This type of research is non-experimental and carried out retrospectively. With the sampling technique according to the inclusion criteria, the data were analyzed univariately and bivariately using SPSS (Friedman, Wilcoxon, Krakall-Wallis, Mann-Whitney, Chi-Square and Fisher Exact tests). The results showed that captopril could lower blood pressure by 25.54/8.51 mmHg and amlodipine could lower blood pressure by 28.64/6.85 mmHg after the 3rd examination. The percenta for the incidence of side effects due to the use of captopril is 98.61% with side effects of dry cough and dry mouth. while for amlodipine 88.88% with a side effect of swelling in the ankles. Comparison of the effectiveness between captopril and amlodipine there is no difference, because the value of Asymp sig. (2-talled) exceeded the value of 0.05, namely on the 2nd examination, systolic blood pressure was 0.519 and diastolic blood pressure was 0.839. The results of the 3rd blood pressure examination showed a systolic value of 0.616 and a diastolic value of 0.313. In the comparison of side effects between captopril and amlodipine, the Asymp sig value was obtained. (2-tailed) exceeds the value of 0.05, which is 0.533, which means that there is no significant difference.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Hipertensi, Efektivitas, Efek Samping, Kaptopril, Amlodipin --- Hypertension, Effectiveness, Side Effects, Kaptopril, Amlodipine |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 07 Sep 2024 02:57 |
| Last Modified: | 07 Sep 2024 02:57 |
| URI: | http://repository.stfi.ac.id/id/eprint/1118 |
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