LYRA AURA NUR SAHAYA, - (2024) DERIVATISASI KUERSETIN DENGAN ASETAT ANHIDRIDA MELALUI REAKSI ESTERIFIKASI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
![[img]](http://repository.stfi.ac.id/style/images/fileicons/text.png) |
Text
S_PSSF_A201017_Title.pdf Download (300kB) |
|
Text
S_PSSF_A201017_Chapter1.pdf Restricted to Repository staff only Download (85kB) |
|
Text
S_PSSF_A201017_Chapter2.pdf Restricted to Repository staff only Download (149kB) |
|
Text
S_PSSF_A201017_Chapter3.pdf Restricted to Repository staff only Download (46kB) |
|
Text
S_PSSF_A201017_Chapter4.pdf Restricted to Repository staff only Download (507kB) |
|
Text
S_PSSF_A201017_Chapter5.pdf Restricted to Repository staff only Download (9kB) |
|
Text
S_PSSF_A201017_Appendix.pdf Restricted to Repository staff only Download (498kB) |
Abstract
Kuersetin merupakan flavonoid yang banyak ditemukan di alam. Kuersetin memiliki berbagai efek farmakologi seperti antioksidan, antinflamasi dan antikanker. Penelitian ini dilakukan untuk menghasilkan senyawa turunan kuersetin melalui reaksi esterifikasi dengan asetat anhidrida. Derivatisasi direaksikan dengan dua pelarut yaitu, DMF dan metanol yang direaksikan dengan menggunakan asetat anhidrida dan piperidin sebagai katalis. Hasil reaksi dipisahkan menggunakan Ekstraksi Cair-Cair (ECC) dan dimurnikan menggunakan kromatografi kolom. Produk hasil reaksi diidentifikasi menggunakan KLT, Spektrofotometri UVVisibel, Fourier Transform Infrared Spectroscopy (FTIR) dan diuji aktivitas antioksidannya. Hasil identifikasi menggunakan KLT terdapat perubahan noda dan nilai Rf. Hasil identifikasi menggunakan Spektrofotometri UV-Visibel didapatkan pergeseran panjang gelombang dari isolat kuersetin 256 nm dan 352 nm menjadi 206 nm pada derivat kuersetin. Hasil identifikasi menggunakan FTIR terdapat gugus fungsi baru dan pergeseran bilangan gelombang. Hasil uji aktivitas antioksidan pada derivat kuersetin didapatkan penurunan dilihat dari nilai IC50 pada kuersetin sebesar 6 g/mL menjadi 162 g/mL. Derivat kuersetin dengan pelarut DMF didapatkan rendemen sebesar 3,37% sedangkan pada pelarut metanol sebesar 11,5%. Derivat kuersetin dengan pelarut metanol memiliki perubahan yang lebih signifikan jika dibandingkan dengan pelarut DMF. ------ Quercetin is a flavonoid that is widely found in nature. Quercetin has various pharmacological effects such as antioxidant, anti-inflammatory and anticancer. This study was conducted to produce quercetin derivative compounds through esterification reactions with acetic anhydride. Derivatization was reacted with two solvents, namely, DMF and methanol which were reacted using acetic anhydride and piperidine as catalysts. The reaction results were separated using LiquidLiquid Extraction (ECC) and purified using column chromatography. The reaction products were identified using TLC, UV-Visible Spectrophotometry, Fourier Transform Infrared Spectroscopy (FTIR) and tested for antioxidant activity. The results of identification using TLC showed changes in spots and Rf values. The results of identification using UV-Visible Spectrophotometry showed a shift in wavelength from quercetin isolates of 256 nm and 352 nm to 206 nm in quercetin derivatives. The results of identification using FTIR showed new functional groups and a shift in wave numbers. The results of the antioxidant activity test on quercetin derivatives showed a decrease seen from the IC50 value of quercetin of 6 g/mL to 162 g/mL. The quercetin derivative with DMF solvent obtained a yield of 3.37% while in methanol solvent it was 11.5%. The quercetin derivative with methanol solvent had a more significant change when compared to DMF solvent.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | derivatisasi, kuersetin, asetat anhidrida, esterifikasi. ---- derivatization, quercetin, acetic anhydride, esterification. |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 28 Aug 2024 04:39 |
| Last Modified: | 28 Aug 2024 04:39 |
| URI: | http://repository.stfi.ac.id/id/eprint/1096 |
Actions (login required)
 |
View Item |
