STUDI INKOMPATIBILITAS SENYAWA ISOLAT CURCUMIN TERHADAP BAHAN PENGIKAT (BINDER) PADA SEDIAAN SOLID TABLET

MEITHA AMANDA SARI, - (2024) STUDI INKOMPATIBILITAS SENYAWA ISOLAT CURCUMIN TERHADAP BAHAN PENGIKAT (BINDER) PADA SEDIAAN SOLID TABLET. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Inkompatibilitas suatu obat dapat berakibat pada hilangnya potensi pada obat dan meningkatnya toksisitas atau efek samping obat. Tujuan penelitian ini untuk memperoleh data perubahan fisik yang diduga sebagai inkompatibilitas antara zat aktif isolat kurkumin dengan beberapa eksipien yang digunakan dalam formulasi sediaan solid, diantaranya polietilen glikol 6000 (PEG 6000), gelatin dan polivinilpirolidone (PVP). Metode yang digunakan meliputi analisis kristal dengan x-ray diffractometry (XRD) dan analisis termal dengan (Differential Scanning Calorimetry) DSC. Berdasarkan hasil penelitian pada analisis homogenitas kurkumin dengan polietilen glikol 6000 (PEG 6000) dan gelatin homogen, sedangkan kurkumin dengan polivinilpirolidone (PVP) tidak homogen. Tidak terjadi perubahan organolaptis pada semua campuran. Pada analisis kristalinitas terjadi kenaikan nilai kristalinitas pada semua campuran. Dan pada pengujian (Differential Scanning Calorimetry) DSC terjadi pergeseran titik leleh yang signifikan pada ketiga campuran. Dari ketiga sampel dapat disimpulkan bahwa ketiga eksipien yaitu polietilen glikol 6000 (PEG 6000), gelatin dan polivinilpirolidone (PVP) setelah dilakukan pengujian diduga inkompatibel dengan isolat kurkumin, karena memiliki perubahan disetiap pengujian seperti pada pengujian homogenitas, x-ray diffractometry (XRD), dan (Differential Scanning Calorimetry) DSC. ----- Incompatibility of a drug can result in a loss of potency in the drug and increased toxicity or side effects of the drug. The purpose of this study is to obtain data on physical changes that are suspected to be incompatibilities between the active substances of curcumin isolate and several excipients used in the formulation of solid preparations, including polyethylene glycol 6000 (PEG 6000), gelatin and polyvinylpyrolidone (PVP). The methods used include crystal analysis with x-ray diffractometry (XRD) and thermal analysis with DSC (Differential Scanning Calorimetry). Based on the results of the research on the homogeneity analysis of curcumin with polyethylene glycol 6000 (PEG 6000) and homogeneous gelatin, while curcumin with polyvinylpyrolidone (PVP) is not homogeneous. There were no organolaptic changes in all mixtures. In the crystallinity analysis, there was an increase in the crystallinity value of all mixtures. And in the test (Differential Scanning Calorimetry) DSC there was a significant shift in the melting point in all three mixtures. From the three samples, it can be concluded that the three excipients, namely polyethylene glycol 6000 (PEG 6000), gelatin and polyvinylpyroldone (PVP) after testing, are suspected to be incompatible with curcumin isolate, because they have changes in each test such as homogeneity testing, x-ray diffractometry (XRD), and (Differential Scanning Calorimetry) DSC.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Inkompatibilitas, isolat kurkumin, kristalinitas, sifat termal. ------ Incompatibility, curcumin isolate, crystallinity, thermal characteristics
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	28 Aug 2024 04:18
Last Modified:	28 Aug 2024 04:18
URI:	http://repository.stfi.ac.id/id/eprint/1093

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