STUDI INKOMPATIBILITAS ISOLAT KURKUMIN TERHADAP BAHAN TAMBAHAN SELULOSA KOMERSIAL

NABILA HAIFA SOLEHUDIN, - (2024) STUDI INKOMPATIBILITAS ISOLAT KURKUMIN TERHADAP BAHAN TAMBAHAN SELULOSA KOMERSIAL. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Kurkumin (C21H20O6) merupakan senyawa aktif yang terkandung dalam kunyit, memiliki efek farmakologi seperti antihipertensi, antiinflamasi, antioksidan, berpotensi dikembangkan menjadi sediaan tablet. Sebelum diformulasikan menjadi sediaan tablet perlu dilakukan studi inkompatibilitas sebagai tahapan preformulasi. Oleh karena itu, penelitian ini bertujuan untuk mengetahui potensi inkompatibilitas isolat kurkumin dengan eksipien golongan selulosa seperti Hidroxy propyl methyl cellulose (HPMC), Microcrystalline Cellulose (MCC), dan Natrium Carboxsymethyl cellulosa (Na-CMC). Metode penelitian meliputi preparasi sampel, organoleptis, homogenitas, morfologi, kristalinitas, sifat termal, dan Los On Drying (LOD). Campuran kurkumin-eksipien (1:1) dihomogenkan menggunakan roller mixer 60 rpm selama 10 menit. Hasil penelitian menunjukkan bahwa campuran kurkumin dengan eksipien HPMC, MCC, dan NaCMC menunjukkan homogenitas dan stabilitas organoleptis yang baik, tanpa mengalami aglomerasi. Pola difraktogram dan termogram campuran kurkumin dengan HPMC, MCC, dan NaCMC menunjukkan sampel mempertahankan struktur dan bentuknya masing-masing. Hasil LOD dari campuran kurkumin dengan eksipien HPMC dan MCC memenuhi persyaratan, yaitu ≤5% sedangkan pada campuran NaCMC tidak memenuhi persyaratan, yaitu 7,75% . Berdasarkan penelitian ini dapat disimpulkan bahwa kurkumin dengan HPMC, MCC, dan NaCMC memiliki potensi yang rendah untuk inkompatibilitas. Namun, pada campuran kurkumin dan NaCMC perlu diperhatikan mengenai kelembapannya. ---- Curcumin (C21H20O6), an active compound found in turmeric, exhibits various pharmacological effects including antihypertensive, anti-inflammatory, and antioxidant properties. It shows potential for development into tablet formulations. As part of the preformulation stage, an incompatibility study is essential before proceeding with tablet formulation. This study aims to evaluate the potential incompatibility of curcumin isolate with cellulose-based excipients: Hydroxypropyl methylcellulose (HPMC), Microcrystalline Cellulose (MCC), and Sodium Carboxymethyl cellulose (Na-CMC). The research methodology encompassed sample preparation, organoleptic analysis, homogeneity assessment, morphology examination, crystallinity evaluation, thermal property analysis, and Loss On Drying (LOD) determination. Curcumin-excipient mixtures (1:1) were homogenized using a roller mixer at 60 rpm for 10 minutes. Results demonstrated that curcumin mixtures with HPMC, MCC, and Na-CMC exhibited good homogeneity and organoleptic stability without agglomeration. Diffractogram and thermogram patterns of these mixtures indicated that all components retained their respective structures and shapes. LOD results for curcumin mixtures with HPMC and MCC met the ≤5% requirement, while the NaCMC mixture exceeded this limit at 7.75%. This study concludes that curcumin shows a low potential for incompatibility with HPMC, Na-CMC, and MCC. However, the higher LOD value for the Na-CMC mixture warrants further consideration in formulation development.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	kurkumin, inkompatibilitas, HPMC, MCC, NaCMC. ---- Curcumin, Incompatibility, HPMC, MCC, Na-CMC
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	26 Aug 2024 03:19
Last Modified:	26 Aug 2024 03:19
URI:	http://repository.stfi.ac.id/id/eprint/1049

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